N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

Base Information

Chemical Name:N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
CAS No.:1101118-17-5
Molecular Formula:C₁₆H₁₄ClN₅O₄S
Molecular Weight:407.837
Hs Code.:

Synonyms:N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

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Chemical Property of N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

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Technology Process of N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

There total 7 articles about N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₉H₉ClN₄

: 121-02-8
2-methyl-5-nitrobenzene-1-sulfonyl chloride

: 1101118-17-5
N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: With sodium hydrogencarbonate; In methanol; for 0.5h;
DOI:10.1016/j.bmc.2011.11.029

Reference yield:

: 1101120-33-5
5-[(tert-butoxycarbonyl)amino]pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester

: 1101118-17-5
N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dichloromethane / 18 h / 20 °C

2.1: sulfuric acid; water / 18 h / Reflux

2.2: pH 12

3.1: hydrogenchloride; copper(l) chloride; sodium nitrite / water / 0.78 h / 0 - 80 °C

3.2: pH 10

4.1: trichlorophosphate / 2 h / 20 °C / Inert atmosphere

4.2: pH 10

5.1: sodium hydrogencarbonate / methanol

6.1: sodium hydrogencarbonate / methanol / 0.5 h

With hydrogenchloride; sulfuric acid; water; sodium hydrogencarbonate; copper(l) chloride; sodium nitrite; trichlorophosphate; In methanol; dichloromethane; water; 4.1: Vilsmeier formylation;
DOI:10.1016/j.bmc.2011.11.029

Reference yield:

: ethyl 5-aminopyrazolo[1,5-a]pyridine-3-carboxylate trifluoroacetate

: 1101118-17-5
N'-((5-chloropyrazolo[1,5-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid; water / 18 h / Reflux

1.2: pH 12

2.1: hydrogenchloride; copper(l) chloride; sodium nitrite / water / 0.78 h / 0 - 80 °C

2.2: pH 10

3.1: trichlorophosphate / 2 h / 20 °C / Inert atmosphere

3.2: pH 10

4.1: sodium hydrogencarbonate / methanol

5.1: sodium hydrogencarbonate / methanol / 0.5 h

With hydrogenchloride; sulfuric acid; water; sodium hydrogencarbonate; copper(l) chloride; sodium nitrite; trichlorophosphate; In methanol; water; 3.1: Vilsmeier formylation;
DOI:10.1016/j.bmc.2011.11.029