rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Base Information

Chemical Name:rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine
CAS No.:125031-17-6
Molecular Formula:C₁₅H₁₀ClIN₄OS
Molecular Weight:456.694
Hs Code.:

Synonyms:rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

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Chemical Property of rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

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Technology Process of rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

There total 6 articles about rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 125031-16-5
rac-6-acetoxy-4-(2-chlorophenyl)-2-iodo-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

: 125031-17-6
rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Guidance literature:: With sodium hydroxide; In methanol; for 0.5h; Ambient temperature;
DOI:10.1021/jm00107a048

Reference yield:

: 67860-46-2
5-(2-chlorophenyl)-2-hydrazino-7-iodo-3H-thieno<2,3-e><1,4>diazepine

: 125031-17-6
rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Guidance literature:: Multi-step reaction with 4 steps

1: 74.5 percent / p-TSA / ethyl acetate / 0.5 h / Heating

2: 72 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / Ambient temperature

3: 64 percent / pyridine / 4 h / Heating

4: 76 percent / 3 N aq. NaOH / methanol / 0.5 h / Ambient temperature

With pyridine; sodium hydroxide; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; ethyl acetate;
DOI:10.1021/jm00107a048

Reference yield:

: 67860-41-7
4-(2-chlorophenyl)2-iodo-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine

: 125031-17-6
rac-4-(2-chlorophenyl)-2-iodo-6-hydroxy-9-methyl-6H-thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / 3-chloroperoxybenzoic acid / CH₂Cl₂ / Ambient temperature

2: 64 percent / pyridine / 4 h / Heating

3: 76 percent / 3 N aq. NaOH / methanol / 0.5 h / Ambient temperature

With pyridine; sodium hydroxide; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1021/jm00107a048