(R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran

Base Information

Chemical Name:(R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran
CAS No.:121620-32-4
Molecular Formula:C₂₆H₃₈O₂S₂Si
Molecular Weight:474.804
Hs Code.:

Synonyms:(R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran

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Technology Process of (R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran

There total 4 articles about (R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 121620-31-3
(R)-2-<(tert-butyldiphenylsiloxy)methyl>dihydro-2H-pyran-3(4H)-one

: 75-08-1
ethanethiol

: 121620-32-4
(R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran

Guidance literature:: With titanium tetrachloride; In dichloromethane; 1.) -50 deg C, 30 min, 2.) -50 to -10 deg C, 30 min;
DOI:10.1021/ja00196a042

Reference yield:

: 51450-45-4
(2R,3S)-2-hydroxymethyltetrahydropyran-3-ol

: 121620-32-4
(R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / dimethylformamide / 1.5 h / 0 °C

2: 92 percent / DMSO, (COCl)2 / CH₂Cl₂ / 0.75 h / -78 °C

3: 88 percent / TiCl₄, / CH₂Cl₂ / 1.) -50 deg C, 30 min, 2.) -50 to -10 deg C, 30 min

With oxalyl dichloride; titanium tetrachloride; dimethyl sulfoxide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00196a042

Reference yield:

: 121620-30-2
1,5-anhydro-6-O-(tert-butyldiphenylsiloxy)-4-hydroxy-2,3-dideoxy-D-erythro-hexitol

: 121620-32-4
(R)-2-<(tert-butyldiphenylsiloxy)methyl>3,3-bis(ethylthio)tetrahydro-2H-pyran

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / DMSO, (COCl)2 / CH₂Cl₂ / 0.75 h / -78 °C

2: 88 percent / TiCl₄, / CH₂Cl₂ / 1.) -50 deg C, 30 min, 2.) -50 to -10 deg C, 30 min

With oxalyl dichloride; titanium tetrachloride; dimethyl sulfoxide; In dichloromethane;
DOI:10.1021/ja00196a042