(+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate

Base Information

• Chemical Name: (+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate
• CAS No.: 1393126-67-4
• Molecular Formula: C₂₉H₃₁N₅O₃
• Molecular Weight: 497.597
• Mol file: 1393126-67-4.mol

Synonyms:(+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate

Chemical Property of (+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate

There total 6 articles about (+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl 3-(4-butyrylbenzamido)propanoate (1383803-08-4) + 6-(4-phenyl-1H-pyrazol-1-yl)pyridin-3-amine (1393125-41-1) → (+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate (1393126-67-4)

Guidance literature:

decaborane; In methanol; at 20 ℃; for 18h;

Reference yield:

2-fluoro-5-iodopyridine (171197-80-1) → (+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate (1393126-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 21 h / 85 °C

2: potassium carbonate; ammonium hydroxide / 4R-4-hydroxyproline; copper(l) iodide / dimethyl sulfoxide / 18 h / 80 °C / Inert atmosphere

3: decaborane / methanol / 18 h / 20 °C

With ammonium hydroxide; potassium carbonate; copper(l) iodide; decaborane; 4R-4-hydroxyproline; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

4-butyrylbenzoic acid methyl ester (71616-83-6) → (+/-)-methyl 3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoate (1393126-67-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide; methanol / tetrahydrofuran / 3 h / 50 °C

1.2: pH 5

2.1: 1-hydroxy-7-aza-benzotriazole; triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 19 h / 20 °C

3.1: decaborane / methanol / 18 h / 20 °C

With methanol; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; decaborane; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

2-fluoro-5-iodopyridine

4-butyrylbenzoic acid methyl ester

4-phenyl-1H-pyrazole

4-butyrylbenzoic acid

Downstream raw materials:

(R)-3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoic acid

(S)-3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoic acid

(+/-)-3-(4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridine-3-ylamino)butyl)benzamido)propanoic acid