(RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid

Base Information

Chemical Name:(RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid
CAS No.:247904-36-5
Molecular Formula:C₃₃H₃₈FN₅O₉S
Molecular Weight:699.757
Hs Code.:

(RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid

Synonyms:(RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid

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Chemical Property of (RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid

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Technology Process of (RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid

There total 2 articles about (RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247904-34-3
(RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

: 247904-36-5
(RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / acetic acid / 2 h / 20 °C

2: HOBT; Et₃N / dimethylformamide; dimethylsulfoxide / 0.75 h / 20 °C

With hydrogen; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Hydrogenation / 2: Condensation;
DOI:10.1021/jm9803727

Reference yield:

: 153538-13-7
pentafluorophenyl 4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>-2-fluorobenzoate

: 247904-35-4
(RS)-2-amino-4-(N-acetylaminosulfonyl)butanoic acid

: 247904-36-5
(RS)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(N-acetylaminosulfonyl)butanoic acid

Guidance literature:: With benzotriazol-1-ol; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 20 ℃; for 0.75h;
DOI:10.1021/jm9803727