(RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

Base Information

Chemical Name:(RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester
CAS No.:247904-34-3
Molecular Formula:C₂₁H₂₄N₂O₇S
Molecular Weight:448.497
Hs Code.:

Synonyms:(RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

Suppliers and Price of (RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

There total 2 articles about (RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 75-36-5
acetyl chloride

: 247904-33-2
(RS)-2-(benzyloxycarbonylamino)-4-(aminosulfonyl)butanoic acid benzyl ester

: 247904-34-3
(RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/jm9803727

Reference yield:

: 69164-71-2
(RS)-2-(benzyloxycarbonylamino)-4-(chlorosulfonyl)butanoic acid benzyl ester

: 247904-34-3
(RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / ammonia in CHCl₃ / 0.5 h

2: 58 percent / 4-(dimethylamino)pyridine; i-Pr₂EtN / dimethylformamide / 16 h / 20 °C

With dmap; ammonia; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 1: Substitution / 2: Acetylation;
DOI:10.1021/jm9803727

Reference yield:

: 247904-34-3
(RS)-2-(benzyloxycarbonylamino)-4-(N-acetylaminosulfonyl)butanoic acid benzyl ester

: 4-acetylsulfamoyl-2-{4-[(2,7-dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / acetic acid / 2 h / 20 °C

2: HOBT; Et₃N / dimethylformamide; dimethylsulfoxide / 0.75 h / 20 °C

3: 76 percent / ammonia in MeOH / 16 h / 20 °C

With ammonia; hydrogen; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Hydrogenation / 2: Condensation / 3: Saponification;
DOI:10.1021/jm9803727