(1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

Base Information

Chemical Name:(1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid
CAS No.:503305-89-3
Molecular Formula:C₂₆H₃₀N₂O₉
Molecular Weight:514.532
Hs Code.:

(1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

Synonyms:(1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

Suppliers and Price of (1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

There total 5 articles about (1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 503305-87-1
(1aS,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-4-(methoxymethoxy)-7-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

: 503305-89-3
(1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

: 503305-88-2
(1aS,8R,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

Guidance literature:: (1aS,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-4-(methoxymethoxy)-7-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid; With lithium diisopropyl amide; In N,N-dimethyl-formamide; at -45 ℃;

formaldehyd; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/anie.200290015

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 503305-89-3
(1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / DIPEA / CH₂Cl₂ / 48 h

2.1: 80 percent / tris(dimethylamino)sulfur(trimethylsilyl)difluoride (TASF) / dimethylformamide; H₂O / 4 h / 20 °C

3.1: 75 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h

4.1: LDA / dimethylformamide / 0.25 h / -45 °C

4.2: dimethylformamide; tetrahydrofuran / 0.75 h / -45 °C

With tris(dimethylamino)sulfonium trimethylsilyldifluoride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo035828t

Reference yield:

: 477223-17-9
9-(diethyl-isopropyl-silanyloxy)-7-methoxymethoxy-1a,2,3,8,9,9a-hexahydro-1,3-diaza-benzo[a]cyclopropa[e]cyclooctene-1,5-dicarboxylic acid dimethyl ester

: 503305-89-3
(1aS,8S,9aS)-dimethyl ester 1a,2,3,8,9,9a-hexahydro-8-(hydroxymethyl)-7-(methoxymethoxy)-3-[(4-methoxyphenyl)methyl]-9-oxo-1H-azirino[2,3-c][1]benzazocine-1,5-dicarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / DIPEA / CH₂Cl₂ / 48 h

2.1: 80 percent / tris(dimethylamino)sulfur(trimethylsilyl)difluoride (TASF) / dimethylformamide; H₂O / 4 h / 20 °C

3.1: 75 percent / Dess-Martin periodinane / CH₂Cl₂ / 1.5 h

4.1: LDA / dimethylformamide / 0.25 h / -45 °C

4.2: dimethylformamide; tetrahydrofuran / 0.75 h / -45 °C

With tris(dimethylamino)sulfonium trimethylsilyldifluoride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; In dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo035828t