6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid

Base Information

Chemical Name:6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid
CAS No.:1044872-63-0
Molecular Formula:C₁₉H₂₈N₂O₇
Molecular Weight:396.441
Hs Code.:

Synonyms:6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid

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Chemical Property of 6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid

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Technology Process of 6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid

There total 7 articles about 6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1044872-62-9
(2-bromo-3,5-dimethoxy-4-morpholin-4-ylmethyl-phenyl)-carbamic acid tert-butyl ester

: 124-38-9,18923-20-1
carbon dioxide

: 1044872-63-0
6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid

Guidance literature:: (2-bromo-3,5-dimethoxy-4-morpholin-4-ylmethyl-phenyl)-carbamic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 1.5h;

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.5h;

carbon dioxide; With water; tert.-butyl lithium; more than 3 stages;

Reference yield:

: 1044872-61-8
(2-bromo-4-bromomethyl-3,5-dimethoxy-phenyl)-carbamic acid tert-butyl ester

: 1044872-63-0
6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / 7 h / 20 °C

2.1: sodium hydride; tert.-butyl lithium; n-butyllithium / tetrahydrofuran; mineral oil / 4 h / -78 - 20 °C

2.2: 8 h / 20 °C

With n-butyllithium; tert.-butyl lithium; sodium hydride; In tetrahydrofuran; mineral oil;

Reference yield:

: 22794-95-2
1-bromo-2,4-dimethoxy-3-methylbenzene

: 1044872-63-0
6-tert-butoxycarbonylamino-2,4-dimethoxy-3-morpholin-4-ylmethyl-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonia; potassium; ferric nitrate / tetrahydrofuran / 4 h / -78 - 0 °C

2.1: potassium carbonate / water; 1,4-dioxane / 14 h / 20 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 2 h / 80 °C

4.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 4 h / 80 °C

5.1: tetrahydrofuran / 7 h / 20 °C

6.1: sodium hydride; tert.-butyl lithium; n-butyllithium / tetrahydrofuran; mineral oil / 4 h / -78 - 20 °C

6.2: 8 h / 20 °C

With N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); ammonia; tert.-butyl lithium; potassium; sodium hydride; potassium carbonate; ferric nitrate; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; water; mineral oil;