(R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid]

Base Information

• Chemical Name: (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid]
• CAS No.: 1537890-05-3
• Molecular Formula: C₂₀H₂₈N₂O₈P₂
• Molecular Weight: 486.398
• Mol file: 1537890-05-3.mol

Synonyms:(R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid]

Chemical Property of (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid]

There total 2 articles about (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate] (1537890-04-2) → (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid] (1537890-05-3)

Guidance literature:

With trimethylsilyl bromide; In acetonitrile; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.tet.2013.12.042

Reference yield:

(R,R)-N,N'-bis(salicylidene)-1,2-cyclohexanediamine (3187-83-5,41013-27-8,41013-28-9,64346-55-0,150026-23-6,133695-16-6,176776-60-6) → (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid] (1537890-05-3)

Guidance literature:

Multi-step reaction with 2 steps

1: calcium chloride; sodium hydride / diethyl ether; mineral oil / 0 - 20 °C

2: trimethylsilyl bromide / acetonitrile / 4 h / 0 - 20 °C

With trimethylsilyl bromide; sodium hydride; calcium chloride; In diethyl ether; acetonitrile; mineral oil;

DOI:10.1016/j.tet.2013.12.042

upstream raw materials:

tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate]

(R,R)-N,N'-bis(salicylidene)-1,2-cyclohexanediamine