tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate]

Base Information

• Chemical Name: tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate]
• CAS No.: 1537890-04-2
• Molecular Formula: C₂₄H₃₆N₂O₈P₂
• Molecular Weight: 542.506
• Mol file: 1537890-04-2.mol

Synonyms:tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate]

Chemical Property of tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate]

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate]

There total 1 articles about tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(R,R)-N,N'-bis(salicylidene)-1,2-cyclohexanediamine (3187-83-5,41013-27-8,41013-28-9,64346-55-0,150026-23-6,133695-16-6,176776-60-6) + Dimethyl phosphite (868-85-9) → tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate] (1537890-04-2) + C24H36N2O8P2

Guidance literature:

With sodium hydride; calcium chloride; In diethyl ether; mineral oil; at 0 - 20 ℃; diastereoselective reaction;

DOI:10.1016/j.tet.2013.12.042

Reference yield: 21.0%

tetramethyl (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)methylphosphonate] (1537890-04-2) → (R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid] (1537890-05-3)

Guidance literature:

With trimethylsilyl bromide; In acetonitrile; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.tet.2013.12.042

upstream raw materials:

(R,R)-N,N'-bis(salicylidene)-1,2-cyclohexanediamine

Dimethyl phosphite

Downstream raw materials:

(R,R)-1,2-cyclohexylenediamino-di-(R,R)-[(2-hydroxyphenyl)-methylphosphonic acid]