1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil

Base Information

Chemical Name:1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil
CAS No.:124424-35-7
Molecular Formula:C₂₉H₂₅FN₂O₅
Molecular Weight:500.526
Hs Code.:

Synonyms:1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil

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Chemical Property of 1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil

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Technology Process of 1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil

There total 6 articles about 1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

: 124424-34-6
O-2,3'-anhydro-1-<5-O-(monomethoxytrityl)-2-deoxy-2-fluoro-β-D-lyxofuranosyl>uracil

: 124424-35-7
1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; for 1h; Ambient temperature;
DOI:10.1021/jm00170a017

Reference yield:

: 69123-98-4
fialuridine

: 124424-35-7
1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil

Guidance literature:: Multi-step reaction with 5 steps

1: 90.3 percent / H₂, Et₃N / 10percent Pd/C / methanol; H₂O / 18 h / 2068.6 Torr

2: 89.3 percent / pyridine / 18 h / Ambient temperature

3: 100 percent / pyridine / 16 h / 0 °C

4: 83.5 percent / 1 N aq. NaOH / ethanol / 4 h / Heating

5: 95.2 percent / t-BuOK / dimethylsulfoxide / 1 h / Ambient temperature

With pyridine; sodium hydroxide; potassium tert-butylate; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; water; dimethyl sulfoxide;
DOI:10.1021/jm00170a017

Reference yield:

: 124424-27-7
1-<5-O-(momomethoxytrityl)-2-deoxy-2-fluoro-β-D-arabinofuranosyl>uracil

: 124424-35-7
1-<5-O-(monomethoxytrityl)-2-fluoro-2,3-dideoxy-β-D-glycero-pent-2-enofuranosyl>uracil

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / pyridine / 16 h / 0 °C

2: 83.5 percent / 1 N aq. NaOH / ethanol / 4 h / Heating

3: 95.2 percent / t-BuOK / dimethylsulfoxide / 1 h / Ambient temperature

With pyridine; sodium hydroxide; potassium tert-butylate; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00170a017