1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione

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Chemical Name:1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione
CAS No.:78103-19-2
Molecular Formula:C₃₀H₃₆N₂O₇Si
Molecular Weight:564.711
Hs Code.:

Synonyms:1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione

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Chemical Property of 1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione

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Technology Process of 1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione

There total 4 articles about 1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4330-34-1
methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose

: 78103-19-2
1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / HCl / acetic acid

2: 31.5 percent / (CH₃)3SiOSO₂CF₃ / 1,2-dichloro-ethane; acetonitrile / 3 h / 24 °C

3: xylene / Heating

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; In acetic acid; 1,2-dichloro-ethane; acetonitrile; xylene;

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 78103-19-2
1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 31.5 percent / (CH₃)3SiOSO₂CF₃ / 1,2-dichloro-ethane; acetonitrile / 3 h / 24 °C

2: xylene / Heating

trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; acetonitrile; xylene;

Reference yield:

: 31167-05-2
2,4-bis-trimethylsilyloxy-5-ethylpyrimidine

: 78103-19-2
1-(2-deoxy-3,5-di-O-p-toluoyl-α-D-ribofuranosyl)-4-trimethylsilyloxy-5-ethyl-2,4(1H,3H)-pyrimidinedione

Guidance literature:: Multi-step reaction with 2 steps

1: 15.3 percent / (CH₃)3SiOSO₂CF₃ / 1,2-dichloro-ethane; acetonitrile / 3 h / 24 °C

2: xylene / Heating

trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; acetonitrile; xylene;