(2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid

Base Information

Chemical Name:(2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid
CAS No.:618448-69-4
Molecular Formula:C₁₇H₂₆O₃
Molecular Weight:278.392
Hs Code.:

Synonyms:(2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid

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Chemical Property of (2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid

Chemical Property:

Purity/Quality:

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Technology Process of (2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid

There total 6 articles about (2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2R,3R,4R)-3-Benzyloxy-2,4,6-trimethyl-heptanal

: 618448-69-4
(2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid

Guidance literature:: With sodium hypochlorite; aminosulfonic acid; In 1,4-dioxane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jo034738l

Reference yield:

: 192060-46-1
[1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

: 618448-69-4
(2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / LiAlH₄; ethyl acetate / hexane; tetrahydrofuran / 1 h / 0 °C

2: 400 mg / BF₃*Et₂O / tetrahydrofuran / 4 h / -78 °C

3: 96 percent / triflic acid / CH₂Cl₂; cyclohexane / 4 h / 20 °C

4: OsO₄; 4-methylmorpholine N-oxide; aq. NaIO₄ / dioxane / 1.5 h / 20 °C

5: 634 mg / aq. NaOCl; H₂NSO₃H / dioxane / 2 h / 0 - 20 °C

With sodium hypochlorite; sodium periodate; osmium(VIII) oxide; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; aminosulfonic acid; ethyl acetate; 4-methylmorpholine N-oxide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; cyclohexane;
DOI:10.1021/jo034738l

Reference yield:

: 620161-26-4
(2R)-2,4-dimethylpentanal

: 618448-69-4
(2R,3R,4R)-2,4,6-trimethyl-3-benzyloxyheptanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 400 mg / BF₃*Et₂O / tetrahydrofuran / 4 h / -78 °C

2: 96 percent / triflic acid / CH₂Cl₂; cyclohexane / 4 h / 20 °C

3: OsO₄; 4-methylmorpholine N-oxide; aq. NaIO₄ / dioxane / 1.5 h / 20 °C

4: 634 mg / aq. NaOCl; H₂NSO₃H / dioxane / 2 h / 0 - 20 °C

With sodium hypochlorite; sodium periodate; osmium(VIII) oxide; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; aminosulfonic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane;
DOI:10.1021/jo034738l