[1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Base Information

Chemical Name:[1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide
CAS No.:192060-46-1
Molecular Formula:C₁₇H₂₇NO₂
Molecular Weight:277.407
Hs Code.:

Synonyms:[1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Suppliers and Price of [1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

There total 3 articles about [1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 513-38-2
Isobutyl iodide

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 192060-46-1
[1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Guidance literature:: With n-butyllithium; diisopropylamine; lithium chloride; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 13h;
DOI:10.1021/jo034738l

Reference yield:

: 90-82-4,7009-81-6,90-83-5,6912-63-6
pseudoephedrine

: 192060-46-1
[1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / Et₃N / CH₂Cl₂ / 0.5 h / 23 °C

2: 89 percent / LiCl, diisopropylamine, n-BuLi / tetrahydrofuran / 6 h / 0 °C

With n-butyllithium; triethylamine; diisopropylamine; lithium chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja970402f

Reference yield:

: 159213-03-3
N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N-methylpropionamide

: 192060-46-1
[1S,2S(R)]-N-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethylpentionamide

Guidance literature:: With lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; at -78 - 5 ℃; for 18h; Inert atmosphere;
DOI:10.1021/ja502744a