racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide

Base Information

• Chemical Name: racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide
• CAS No.: 134198-10-0
• Molecular Formula: C₁₂H₁₄BrNO₂
• Molecular Weight: 284.153
• Mol file: 134198-10-0.mol

Synonyms:racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide

Chemical Property of racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide

There total 1 articles about racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-3-(4-bromophenyl)-N-methoxy-N-methylacrylamide (201996-64-7) → racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide (134198-10-0)

Guidance literature:

trimethylsulfoxonium iodide; With sodium hydride; In dimethyl sulfoxide; at 0 - 20 ℃; for 0.75h;

(E)-3-(4-bromophenyl)-N-methoxy-N-methylacrylamide;

Reference yield: 93.0%

racemic 2-(4-bromo-phenyl)-trans-cyclopropanecarboxylic acid N-methoxy-N-methyl-amide (134198-10-0) → trans-(1S,2S)/(1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylic acid (6142-65-0,31501-85-6,77255-26-6,2137065-16-6)

Guidance literature:

With potassium tert-butylate; In diethyl ether; water;

DOI:10.1016/S0040-4039(00)79644-4

upstream raw materials:

(E)-3-(4-bromophenyl)-N-methoxy-N-methylacrylamide

Downstream raw materials:

trans-(1S,2S)/(1R,2R)-2-(4-bromophenyl)cyclopropanecarboxylic acid