di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate

Base Information

Chemical Name:di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate
CAS No.:737830-22-7
Molecular Formula:C₅₀H₅₉F₃N₂O₁₆
Molecular Weight:1001.02
Hs Code.:

di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate

Synonyms:di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate

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Chemical Property of di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate

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Technology Process of di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate

There total 3 articles about di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 737830-11-4
6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-carbaldehyde

: 737830-22-7
di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / NaBH₄ / methanol / 3 h / 20 °C

2: tetrahydrofuran / 2 h / Heating

3: 111 mg / i-Pr₂NEt / CH₂Cl₂ / 0.17 h

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2004.04.011

Reference yield:

: 737830-13-6
6,7-bis(tert-butoxycarbonylmethoxy)-4-(hydroxymethoxy)coumarin

: 737830-22-7
di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 2 h / Heating

2: 111 mg / i-Pr₂NEt / CH₂Cl₂ / 0.17 h

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2004.04.011