(2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid

Base Information

Chemical Name:(2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid
CAS No.:811412-49-4
Molecular Formula:C₃₄H₂₇F₃N₂O₁₆
Molecular Weight:776.587
Hs Code.:

Synonyms:(2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid

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Chemical Property of (2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid

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Technology Process of (2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid

There total 4 articles about (2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 737830-22-7
di-tert-butyl (2S,3S)-N-[6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-yl-methoxy]carbonyl-3-{3-[4-(trifluoromethyl)benzoyl]aminobenzyloxy}aspartate

: 811412-49-4
(2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 5h;
DOI:10.1016/j.bmc.2004.04.011

Reference yield:

: 737830-11-4
6,7-bis(tert-butoxycarbonylmethoxy)coumarin-4-carbaldehyde

: 811412-49-4
(2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 64 percent / NaBH₄ / methanol / 3 h / 20 °C

2: tetrahydrofuran / 2 h / Heating

3: 111 mg / i-Pr₂NEt / CH₂Cl₂ / 0.17 h

4: 49 percent / TFA / CH₂Cl₂ / 5 h / 0 - 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.bmc.2004.04.011

Reference yield:

: 737830-13-6
6,7-bis(tert-butoxycarbonylmethoxy)-4-(hydroxymethoxy)coumarin

: 811412-49-4
(2S,3S)-2-(6,7-Bis-carboxymethoxy-2-oxo-2H-chromen-4-ylmethoxycarbonylamino)-3-[3-(4-trifluoromethyl-benzoylamino)-benzyloxy]-succinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / Heating

2: 111 mg / i-Pr₂NEt / CH₂Cl₂ / 0.17 h

3: 49 percent / TFA / CH₂Cl₂ / 5 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmc.2004.04.011