2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Base Information

• Chemical Name: 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
• CAS No.: 1194030-71-1
• Molecular Formula: C₁₈H₂₅NO₅
• Molecular Weight: 335.4
• Mol file: 1194030-71-1.mol

Synonyms:2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Chemical Property of 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

There total 12 articles about 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.8%

rac-1-tert-butyl 2-methyl 2-[(benzyloxy)methyl]pyrrolidine-1,2-dicarboxylate (1206898-37-4) → 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (1194030-71-1)

Guidance literature:

With sodium hydroxide; In methanol; water; at 70 ℃; for 16h;

Reference yield: 52.0%

1-tert-butyl 2-ethyl 2-((benzyloxy)methyl)pyrrolidine-1,2-dicarboxylate (1621482-38-9) → 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (1194030-71-1)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; methanol; at 65 ℃; for 16h;

Reference yield:

Benzyloxymethyl chloride (3587-60-8) + 1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) → 2-((benzyloxy)methyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (1194030-71-1)

Guidance literature:

1-(tert-butoxycarbonyl)-L-proline; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; at 0 ℃;

Benzyloxymethyl chloride; In tetrahydrofuran; n-heptane; at 20 ℃;

With hydrogenchloride; water; In tetrahydrofuran; n-heptane;

upstream raw materials:

Benzyloxymethyl chloride

1-(tert-butoxycarbonyl)-L-proline

methyl pyrrolidine-2-carboxylate

(+/-)-N-tert-butoxycarbonylproline methyl ester

Downstream raw materials:

tert-butyl 2-(benzyloxymethyl)-2-(2-oxo-2-(pyrrolidin-1-yl)ethylcarbamoyl)pyrrolidine-1-carboxylate

tert-butyl 2-((benzyloxy)methyl)-2-(((2S,3R)-3-hydroxy-1-methoxy-1-oxobutan-2-yl)carbamoyl)pyrrolidine-1-carboxylate

tert-butyl-2-(((2S,3R)-3-acetoxy-1-methoxy-1-oxobutan-2-yl)carbamoyl)-2-((benzyloxy)methyl)pyrrolidine-1-carboxylate

(2S,3R)-3-hydroxy-2-(5-isobutyryl-1-oxo-2,5-diazaspiro[3.4]octan-2-yl)butanamide