N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Base Information

Chemical Name:N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide
CAS No.:1352086-12-4
Molecular Formula:C₁₉H₂₄N₄O₂
Molecular Weight:340.425
Hs Code.:

N<sup>2</sup>-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Synonyms:N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Suppliers and Price of N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

There total 15 articles about N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352086-71-5
N²-tert-butyl-6-chloro-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

: 1352086-12-4
N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; for 6h; Reflux;

Reference yield:

: 1885-38-7
cinnamic nitrile

: 1352086-12-4
N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.5 h / 20 - 25 °C

2.1: N-chloro-succinimide / tetrahydrofuran / 48 h / Reflux

3.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile

3.2: 4 h / Reflux

4.1: hydrogenchloride / ethanol; water / 1 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 4 h / Heating

6.1: dichloromethane / 4 h / 20 °C

7.1: sodium hydroxide; water; dihydrogen peroxide / dimethyl sulfoxide; methanol / 1.25 h / 65 °C

8.1: ammonium formate / palladium 10% on activated carbon / methanol / 6 h / Reflux

With hydrogenchloride; N-chloro-succinimide; potassium tert-butylate; water; dihydrogen peroxide; ammonium formate; sodium hydroxide; palladium 10% on activated carbon; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 40167-37-1
4-phenyl-1H-pyrrole-3-carbonitrile

: 1352086-12-4
N²-tert-butyl-7-phenyl-3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1H)-dicarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-chloro-succinimide / tetrahydrofuran / 48 h / Reflux

2.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / acetonitrile

2.2: 4 h / Reflux

3.1: hydrogenchloride / ethanol; water / 1 h / 90 °C

4.1: hydrogenchloride / ethanol; water / 4 h / Heating

5.1: dichloromethane / 4 h / 20 °C

6.1: sodium hydroxide; water; dihydrogen peroxide / dimethyl sulfoxide; methanol / 1.25 h / 65 °C

7.1: ammonium formate / palladium 10% on activated carbon / methanol / 6 h / Reflux

With hydrogenchloride; N-chloro-succinimide; water; dihydrogen peroxide; ammonium formate; sodium hydroxide; palladium 10% on activated carbon; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; acetonitrile;