3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate

Base Information

Chemical Name:3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate
CAS No.:1363374-84-8
Molecular Formula:C₂₆H₃₂N₄O₇
Molecular Weight:512.563
Hs Code.:

Synonyms:3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate

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Chemical Property of 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate

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Technology Process of 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate

There total 9 articles about 3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1363374-82-6
benzyl ((1S,2S)-2-hydroxy-2-methyl-1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)but-3-yn-1-yl)carbamate

: 622-79-7
benzyl azide

: 1363374-84-8
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate

Guidance literature:: With water; copper(II) sulfate; sodium L-ascorbate; In tert-butyl alcohol; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

: 99314-44-0
(3-methyloxetan-3-yl)methyl 4-methylbenzenesulfonate

: 1363374-84-8
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 36 h / 70 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h

3.1: dichloromethane / -78 °C / Inert atmosphere

3.2: 2.08 h / -78 °C / Inert atmosphere

3.3: 0.67 h / -78 - 0 °C

4.1: isopropylmagnesium bromide / 2-methyltetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

4.2: 2 h / 20 °C

5.1: dichloromethane / -78 °C / Inert atmosphere

5.2: 2.58 h / -78 °C / Inert atmosphere

5.3: 0.67 h / -78 - 0 °C

6.1: tetrahydrofuran / 0.03 h / -78 °C / Inert atmosphere

6.2: 0.25 h / pH 7

7.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

8.1: water; sodium L-ascorbate; copper(II) sulfate / tert-butyl alcohol / 24 h / 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; isopropylmagnesium bromide; tetra-(n-butyl)ammonium iodide; copper(II) sulfate; sodium L-ascorbate; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 3143-02-0
3-hydroxymethyl-3-methyloxethane

: 1363374-84-8
3-hydroxy-2-(hydroxymethyl)-2-methylpropyl (2S,3R)-3-(1-benzyl-1H-1,2,3-triazol-4-yl)-2-(((benzyloxy)carbonyl)amino)-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine / 1.75 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 36 h / 70 °C / Inert atmosphere

3.1: boron trifluoride diethyl etherate / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

3.2: 0.5 h

4.1: dichloromethane / -78 °C / Inert atmosphere

4.2: 2.08 h / -78 °C / Inert atmosphere

4.3: 0.67 h / -78 - 0 °C

5.1: isopropylmagnesium bromide / 2-methyltetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 2 h / 20 °C

6.1: dichloromethane / -78 °C / Inert atmosphere

6.2: 2.58 h / -78 °C / Inert atmosphere

6.3: 0.67 h / -78 - 0 °C

7.1: tetrahydrofuran / 0.03 h / -78 °C / Inert atmosphere

7.2: 0.25 h / pH 7

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.08 h / 0 °C / Inert atmosphere

9.1: water; sodium L-ascorbate; copper(II) sulfate / tert-butyl alcohol / 24 h / 20 °C / Inert atmosphere

With pyridine; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; water; isopropylmagnesium bromide; tetra-(n-butyl)ammonium iodide; copper(II) sulfate; sodium L-ascorbate; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; tert-butyl alcohol;