Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Base Information

Chemical Name:Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester
CAS No.:335259-79-5
Molecular Formula:C₂₂H₃₀O₄S₂Si
Molecular Weight:450.695
Hs Code.:

Synonyms:Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Suppliers and Price of Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

There total 6 articles about Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 335259-76-2
(3R,5R)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-ol

: 335259-79-5
Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 40 ℃; for 24h;
DOI:10.1016/S0960-894X(01)00006-3

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 335259-79-5
Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / imidazole / dimethylformamide / 1.5 h / 20 °C

2: DMAP / acetonitrile / 24 h / 20 °C

3: Et₃B; n-Bu₃SnH / benzene / 0 °C

4: 78 percent / NH₃ / methanol / 24 h / 20 °C

5: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 24 h / 40 °C

With 1H-imidazole; dmap; triethyl borane; ammonia; tri-n-butyl-tin hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0960-894X(01)00006-3

Reference yield:

: 218601-14-0
Benzoic acid (3R,4R,5S)-4-hydroxy-5-hydroxymethyl-tetrahydro-thiophen-3-yl ester

: 335259-79-5
Methanesulfonic acid (3R,5R)-5-(tert-butyl-diphenyl-silanyloxymethyl)-tetrahydro-thiophen-3-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / imidazole / dimethylformamide / 1.5 h / 20 °C

2: DMAP / acetonitrile / 24 h / 20 °C

3: Et₃B; n-Bu₃SnH / benzene / 0 °C

4: 78 percent / NH₃ / methanol / 24 h / 20 °C

5: 99 percent / Et₃N; DMAP / CH₂Cl₂ / 24 h / 40 °C

With 1H-imidazole; dmap; triethyl borane; ammonia; tri-n-butyl-tin hydride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; benzene;
DOI:10.1016/S0960-894X(01)00006-3