(1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:(1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester
CAS No.:959434-85-6
Molecular Formula:C₄₄H₅₆N₄O₈
Molecular Weight:768.951
Hs Code.:

(1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

Synonyms:(1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

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Chemical Property of (1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

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Technology Process of (1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

There total 1 articles about (1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 862175-16-4
(1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid

: 959434-77-6
N'-oct-7-enyl-hydrazinecarboxylic acid tert-butyl ester

: 959434-85-6
(1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16.5h;
DOI:10.1016/j.bmc.2007.07.027

Reference yield: 79.0%

: 959434-85-6
(1R,2S)-1-{[(1R,2R,4R)-2-(N'-tert-butoxycarbonyl-N-oct-7-enyl-hydrazinocarbonyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarbonyl]amino}-2-vinylcyclopropanecarboxylic acid ethyl ester

: 959434-88-9
(Z)-(1R,4R,6S,17R,19R)-15-tert-butoxycarbonylamino-19-(7-methoxy-2-phenyl-quinolin-4-yloxy)-2,16-dioxo-3,15-diaza-tricyclo[15.3.0.0^4,6]icos-7-ene-4-carboxylic acid ethyl ester

Guidance literature:: With [1,3-bis-(2,4,6-trimethylphenyl)-2-imidazolidinylidene]dichloro(O-isopropoxyphenylmethylene)ruthenium; In dichloromethane; for 16h; Heating;
DOI:10.1016/j.bmc.2007.07.027