(1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid

Base Information

Chemical Name:(1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid
CAS No.:862175-16-4
Molecular Formula:C₃₁H₃₂N₂O₇
Molecular Weight:544.604
Hs Code.:

Synonyms:(1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid

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Chemical Property of (1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid

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Technology Process of (1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid

There total 10 articles about (1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862174-63-8
(1R,2R,4S)-2-((1R,2S)-1-ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopenteanecarboxylic acid tert-butyl ester

: 862175-16-4
(1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2006.04.008

Reference yield:

: 259214-54-5,259214-56-7
ethyl (1R,2S)-1-amino-2-vinylcyclopropanecarboxylate hydrochloride

: 862175-16-4
(1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 86 mg / diisopropylethylamine; O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium PF₆ / dimethylformamide / 2.5 h / 0 - 20 °C

2: 68 percent / triphenylphosphine; diisopropyl diazodicarboxylate / tetrahydrofuran / 48 h / 20 °C

3: triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.04.008

Reference yield:

: 862174-60-5
(1R,4R,5R)-3-oxo-2-oxabicyclo[2.2.1]heptane-5-carboxylic acid

: 862175-16-4
(1R,2R,4R)-2-((1R,2S)-1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-cyclopentanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 52 percent / 4-dimethylaminopyridine / CH₂Cl₂ / 0 - 20 °C

2: lithium hydroxide / dioxane; H₂O / 0.75 h / 0 °C

3: 86 mg / diisopropylethylamine; O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium PF₆ / dimethylformamide / 2.5 h / 0 - 20 °C

4: 68 percent / triphenylphosphine; diisopropyl diazodicarboxylate / tetrahydrofuran / 48 h / 20 °C

5: triethylsilane; trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With triethylsilane; dmap; lithium hydroxide; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; 4: Mitsunobu reaction;
DOI:10.1016/j.bmc.2006.04.008