6-(4-FLUOROPHENOXY)PYRIDINE-3-AMINE, 97+%

Base Information

• Chemical Name: 6-(4-FLUOROPHENOXY)PYRIDINE-3-AMINE, 97+%
• CAS No.: 143071-78-7
• Molecular Formula: C11H9 F N2 O
• Molecular Weight: 204.2003632
• Hs Code.: 2933399090
• Mol file: 143071-78-7.mol

Synonyms:5-Amino-2-(4-fluorophenoxy)pyridine;6-(4-Fluorophenoxy)pyridin-3-amine

Chemical Property of 6-(4-FLUOROPHENOXY)PYRIDINE-3-AMINE, 97+%

Chemical Property:

• Vapor Pressure: 2.07E-05mmHg at 25°C
• Refractive Index: 1.605
• Boiling Point: 361.4ºC at 760 mmHg
• Flash Point: 172.4ºC
• PSA: 48.14000
• Density: 1.278g/cm3
• LogP: 3.17640

Purity/Quality:

99.3% ^*data from raw suppliers

6-(4-Fluorophenoxy)pyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(4-FLUOROPHENOXY)PYRIDINE-3-AMINE, 97+%

There total 2 articles about 6-(4-FLUOROPHENOXY)PYRIDINE-3-AMINE, 97+% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 6-(4-fluorophenoxy)pyridin-3-amine (143071-78-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 5h;

Reference yield:

2-(4-fluorophenoxy)-5-nitropyridine (31011-26-4) → 6-(4-fluorophenoxy)pyridin-3-amine (143071-78-7)

Guidance literature:

hydrogenation;

DOI:10.1016/j.bmcl.2007.09.085

Reference yield: 88.0%

rac-5-(4-fluorophenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine + 6-(4-fluorophenoxy)pyridin-3-amine (143071-78-7) + 4-Nitrophenyl chloroformate (7693-46-1) → (rac)-N-[6-(4-fluorophenoxy)pyridin-3-yl]-5-(4-fluorophenyl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxamide

Guidance literature:

6-(4-fluorophenoxy)pyridin-3-amine; 4-Nitrophenyl chloroformate; In tetrahydrofuran; at 20 ℃; for 1h;

rac-5-(4-fluorophenyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; With triethylamine; In tetrahydrofuran; at 60 ℃;

DOI:10.1021/acs.jmedchem.9b01382

upstream raw materials:

2-(4-fluorophenoxy)-5-nitropyridine

Downstream raw materials:

6-(4-fluorophenoxy)pyridin-3-ol

C₁₈H₁₉FN₂O₅

C₁₉H₁₉FN₄O₅