3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

Base Information

• Chemical Name: 3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine
• CAS No.: 100856-28-8
• Molecular Formula: C₁₉H₂₀N₂O₃
• Molecular Weight: 324.379
• Mol file: 100856-28-8.mol

Synonyms:3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

Chemical Property of 3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

There total 7 articles about 3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester (100856-24-4) → 3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine (100856-28-8)

Guidance literature:

With polyphosphoric ester; at 100 - 110 ℃; for 1.5h;

DOI:10.1002/jhet.5570220323

Reference yield:

N-<2-phenyl-5-methylpyrrol-3-yl>aminomethylenemalonic acid, diethyl ester (100856-21-1) → 3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine (100856-28-8)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydride / tetrahydrofuran / 1.) reflux, 2 hrs, 2.) r.t., overnight

2: polyphosphoric ester / 2 h / 100 - 110 °C

3: sodium methoxide / dimethylformamide / r.t., overnight

With polyphosphoric ester; sodium methylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570220323

Reference yield:

2-{[Methyl-(5-methyl-2-phenyl-1H-pyrrol-3-yl)-amino]-methylene}-malonic acid diethyl ester → 3-carbethoxy-7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine (100856-28-8)

Guidance literature:

Multi-step reaction with 2 steps

1: polyphosphoric ester / 2 h / 100 - 110 °C

2: sodium methoxide / dimethylformamide / r.t., overnight

With polyphosphoric ester; sodium methylate; In N,N-dimethyl-formamide;

DOI:10.1002/jhet.5570220323

upstream raw materials:

N-<1,5-dimethyl-2-phenyl-4-carboxypyrrol-3-yl>methylaminomethylenemalonic acid diethyl ester

3-carbethoxy-1,5-dimethyl-7-phenyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine

methyl iodide

N-<2-phenyl-5-methylpyrrol-3-yl>aminomethylenemalonic acid, diethyl ester

Downstream raw materials:

7-phenyl-1,5,6-trimethyl-1,4-dihydro-4-oxopyrrolo<3,4-b>pyridine-3-carboxylic acid