Technology Process of 4,5α-epoxy-3-methoxy-17-methyl-7α-(4-phenyl-1,3-butadienyl)-6β,7β-(oxymethylene)morphinan
There total 7 articles about 4,5α-epoxy-3-methoxy-17-methyl-7α-(4-phenyl-1,3-butadienyl)-6β,7β-(oxymethylene)morphinan which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 13 percent / pyridine / Ambient temperature
2: 73 percent / 1N NaOH / butan-2-one / 2 h / Heating
3: 97 percent / dimethylformamide / 18 h / 100 °C
4: 66 percent / NaOMe / methanol / 0.5 h
5: 72 percent / 1.) TFAA*Me2SO, 2.) TEA / CH2Cl2 / 1.5 h / -60 °C
6: 1.) NaH / 1.) DMSO, 25 deg C, 10 min, 2.) DMSO, room temp., 30 min, 65-70 deg C, 30 min
With
sodium hydroxide; TEA; sodium methylate; sodium hydride; trifluoroacetic anhydride;
In
pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jo00159a005
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 73 percent / 1N NaOH / butan-2-one / 2 h / Heating
2: 97 percent / dimethylformamide / 18 h / 100 °C
3: 66 percent / NaOMe / methanol / 0.5 h
4: 72 percent / 1.) TFAA*Me2SO, 2.) TEA / CH2Cl2 / 1.5 h / -60 °C
5: 1.) NaH / 1.) DMSO, 25 deg C, 10 min, 2.) DMSO, room temp., 30 min, 65-70 deg C, 30 min
With
sodium hydroxide; TEA; sodium methylate; sodium hydride; trifluoroacetic anhydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide; butanone;
DOI:10.1021/jo00159a005
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 72 percent / 1.) TFAA*Me2SO, 2.) TEA / CH2Cl2 / 1.5 h / -60 °C
2: 1.) NaH / 1.) DMSO, 25 deg C, 10 min, 2.) DMSO, room temp., 30 min, 65-70 deg C, 30 min
With
TEA; sodium hydride; trifluoroacetic anhydride;
In
dichloromethane;
DOI:10.1021/jo00159a005
