77794-00-4

Upstream product

• 77793-96-5 7,7-bis(hydroxymethyl)-4,5α-epoxy-3-methoxy-17-methylmorphinan-6β-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 77794-06-0 7,7-bis(hydroxymethyl)-4,5α-epoxy-3-methoxy-17-methylmorphinan-6β-ol hydrochloride 

Downstream Products

• 85455-02-3 4,5α-epoxy-3-methoxy-17-methyl-7β-<(tosyloxy)methyl>-6β,7β-(oxymethylene)morphinan 
• 85455-06-7 4,5α-epoxy-3-methoxy-17-methyl-7β-(4-phenyl-1,3-butadienyl)-6α,7α-(oxymethylene)morphinan 
• 85454-97-3 4,5α-epoxy-3-methoxy-17-methyl-7α-(4-phenyl-1,3-butadienyl)-6β,7β-(oxymethylene)morphinan 
• 85455-10-3 7α,17-dimethyl-4,5α-epoxy-3-methoxy-7β-(4-phenylbutyl)morphinan-6-one 
• 85455-07-8 4,5α-epoxy-3-methoxy-17-methyl-7β-(4-phenylbutyl)-6α,7α-(oxymethylene)morphinan 
• 85454-99-5 4,5α-epoxy-3-methoxy-17-methyl-7α-(4-phenylbutyl)-6β,7β-(oxymethylene)morphinan 
• 85455-08-9 4,5α-epoxy-17-methyl-7β-(4-phenylbutyl)-6α,7α-(oxymethylene)morphinan-3-ol 
• 85455-01-2 7,7-bis<(tosyloxy)methyl>-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol 
• 85454-98-4 7β-(chloromethyl)-4,5α-epoxy-3-methoxy-17-methyl-7α-(4-phenylbutyl)morphinan-6β-ol 
• 85455-25-0 C₂₈H₃₄BrNO₃ 
• 85455-09-0 7α,17-dimethyl-4,5α-epoxy-3-methoxy-7β-(4-phenylbutyl)morphinan-6α-ol 
• 85454-93-9 4,5α-epoxy-3-methoxy-17-methyl-7α-<(tosyloxy)methyl>-6β,7β-(oxymethylene)morphinan 
• 85455-00-1 7,7-bis<(tosyloxy)methyl>-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one 

Relevant academic research and scientific papers

Analgesic narcotic antagonists. 5. 7,7-Dimethyldihydrocodeinones and 7,7-dimethyldihydromorphinones

Treatment of dihydrocodeinone or the 8β-methyl analogues with formaldehyde-Ca(OH)2 in aqueous dioxane gave the corresponding 7,7-bis(hydroxymethyl) 6β-ols. Ditosylation of these, followed by LiEt3BH reduction, gave either the 7,7-dim

7&α- or 7&β-(4-Phenylbutyl)dihydrocodeine Derivatives

A lipophilic 4-phenylbutyl group was selectively incorporated into the 7α- or 7β-position of the morphine nucleus by use of 6,7-oxymethylene (oxetane) intermediates. 7,7-Bisdihydroisocodeine (2) with dilute NaOH gave 6β,7β-(oxymethylene)