(2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine

Base Information

• Chemical Name: (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine
• CAS No.: 205526-45-0
• Molecular Formula: C₂₅H₂₇NO₄
• Molecular Weight: 405.494
• Mol file: 205526-45-0.mol

Synonyms:(2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine

Chemical Property of (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine

There total 3 articles about (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzaldehyde (100-52-7) + ((S)-Methoxy-phenyl-methyl)-[1-(2,4,6-trimethoxy-phenyl)-meth-(E)-ylidene]-amine → (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine (205526-45-0)

Guidance literature:

With 3 A molecular sieve; In benzene; Heating;

DOI:10.3987/COM-98-8211

Reference yield: 81.0%

benzaldehyde (100-52-7) + (R)-N-2,4,6-trimethoxybenzylphenylglycinol (204845-22-7) → (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine (205526-45-0)

Guidance literature:

In benzene; for 15h; Heating;

DOI:10.3987/com-97-s32

Reference yield:

2,4,6-trimethoxybenzaldehyde (830-79-5) → (2R,4R)-N-(2,4,6-trimethoxybenzyl)-2,4-diphenyl-1,3-oxazolidine (205526-45-0)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 1 h / Heating

2: 81 percent / molecular sieves 3 Angstroem / benzene / Heating

With 3 A molecular sieve; In benzene;

DOI:10.3987/COM-98-8211

upstream raw materials:

benzaldehyde

(R)-N-2,4,6-trimethoxybenzylphenylglycinol

2,4,6-trimethoxybenzaldehyde

Downstream raw materials:

(1S,1'R)-1-[N-(2,4,6-trimethoxybenzyl)-N-2'-hydroxy-1'-phenylethylamino]-5,5-ethylenedioxy-1-phenylpentane

(2R,6S)-2,6-diphenylpiperidine

(2S,6R,1'R)-N-2'-hydroxy-1'-phenylethyl-2,6-diphenylpiperidine

(2S)-1-[(1R)-2-hydroxy-1-phenylethyl]-2-phenylpiperidine