2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile

Base Information

Chemical Name:2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile
CAS No.:1363411-32-8
Molecular Formula:C₂₀H₁₈N₂O₃
Molecular Weight:334.375
Hs Code.:

Synonyms:2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile

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Chemical Property of 2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile

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Technology Process of 2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile

There total 6 articles about 2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1242071-55-1
methyl 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate

: 1184040-33-2
C₁₆H₁₆N₂O₂

: 1363411-32-8
2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile

Guidance literature:: methyl 2-(((tert-butoxycarbonyl)oxy)methyl)acrylate; C₁₆H₁₆N₂O₂; With 1,4-diaza-bicyclo[2.2.2]octane; In acetonitrile; at 30 ℃; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 30 - 60 ℃; for 13h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201200642

Reference yield: 70.0%

: 1363411-20-4
C₂₁H₂₂N₂O₄

: 1363411-32-8
2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 - 20 ℃;
DOI:10.1039/c2ob07112f

Reference yield:

: C₁₆H₁₄N₂O₂

: 1363411-32-8
2-(3-methoxyphenyl)-1-(4-methoxyphenyl)-4-methylene-5-oxopyrrolidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / acetonitrile

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile;
DOI:10.1039/c2ob07112f