methyl 3,5-diphenylpent-4-ynoate

Base Information

• Chemical Name: methyl 3,5-diphenylpent-4-ynoate
• CAS No.: 1351953-77-9
• Molecular Formula: C₁₈H₁₆O₂
• Molecular Weight: 264.324
• Mol file: 1351953-77-9.mol

Synonyms:methyl 3,5-diphenylpent-4-ynoate

Chemical Property of methyl 3,5-diphenylpent-4-ynoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3,5-diphenylpent-4-ynoate

There total 5 articles about methyl 3,5-diphenylpent-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methyl 3-(4,5-dihydro-5-oxo-3-phenylisoxazol-4-yl)-3-phenylpropanoate → methyl 3,5-diphenylpent-4-ynoate (1351953-77-9)

Guidance literature:

With ferrous(II) sulfate heptahydrate; sodium nitrite; In water; acetic acid; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01004

Reference yield:

3-phenyl-4-(1-phenylmethylidene)-5-isoxazolone (1088-32-0,36298-61-0) → methyl 3,5-diphenylpent-4-ynoate (1351953-77-9)

Guidance literature:

Multi-step reaction with 2 steps

1: scandium tris(trifluoromethanesulfonate) / dichloromethane / 22 h / 25 °C

2: ferrous(II) sulfate heptahydrate; sodium nitrite / water; acetic acid / 0.5 h / 20 °C / Inert atmosphere

With ferrous(II) sulfate heptahydrate; scandium tris(trifluoromethanesulfonate); sodium nitrite; In dichloromethane; water; acetic acid;

DOI:10.1021/acs.orglett.5b01004

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → methyl 3,5-diphenylpent-4-ynoate (1351953-77-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium acetate / ethanol / Reflux

1.2: Reflux

2.1: piperidine / isopropyl alcohol / 50 °C

3.1: scandium tris(trifluoromethanesulfonate) / dichloromethane / 22 h / 25 °C

4.1: ferrous(II) sulfate heptahydrate; sodium nitrite / water; acetic acid / 0.5 h / 20 °C / Inert atmosphere

With piperidine; ferrous(II) sulfate heptahydrate; hydroxylamine hydrochloride; sodium acetate; scandium tris(trifluoromethanesulfonate); sodium nitrite; In ethanol; dichloromethane; water; acetic acid; isopropyl alcohol;

DOI:10.1021/acs.orglett.5b01004

upstream raw materials:

1,3-diphenyl-1-propyn-3-ol

ethyl 3-oxo-3-phenylpropionate

3-phenyl-4H-isoxazol-5-one

3-phenyl-4-(1-phenylmethylidene)-5-isoxazolone