ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate

Base Information

Chemical Name:ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate
CAS No.:862297-58-3
Molecular Formula:C₄₇H₅₁N₃O₉S₂Si
Molecular Weight:894.154
Hs Code.:

Synonyms:ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate

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Chemical Property of ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate

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Technology Process of ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate

There total 9 articles about ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₁H₄₈N₂O₅SSi

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 862297-58-3
ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate

Guidance literature:: With pyridine; dmap; In chloroform; at 20 ℃; for 16h;
DOI:10.1039/b417625c

Reference yield:

: 862297-62-9
ethyl 5-methyl-3-{[4-(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)indol-3-yl}hex-4-enoate

: 862297-58-3
ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / KHMDS; trisyl azide; AcOH / tetrahydrofuran / -78 °C

2: H₂O; PPH₃ / tetrahydrofuran / 6 h / 60 °C

3: 33 mg / pyridine; DMAP / CHCl₃ / 16 h / 20 °C

With pyridine; dmap; 2,4,6-Triisopropylbenzenesulfonyl azide; water; potassium hexamethylsilazane; acetic acid; triphenylphosphine; In tetrahydrofuran; chloroform;
DOI:10.1039/b417625c

Reference yield:

: 862297-63-0
ethyl 2-azido-5-methyl-3-{4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indol-3-yl}-hex-4-enoate

: 862297-58-3
ethyl 2-(4-nitrobenzenesulfonylamino)-5-methyl-3-[4-[(tert-butyldiphenylsilyloxy)methyl]-1-(4-toluenesulfonyl)-indole-3-yl]-4-hexenoate

Guidance literature:: Multi-step reaction with 2 steps

1: H₂O; PPH₃ / tetrahydrofuran / 6 h / 60 °C

2: 33 mg / pyridine; DMAP / CHCl₃ / 16 h / 20 °C

With pyridine; dmap; water; triphenylphosphine; In tetrahydrofuran; chloroform;
DOI:10.1039/b417625c