(S)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester

Base Information

• Chemical Name: (S)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester
• CAS No.: 916067-33-9
• Molecular Formula: C₂₄H₃₂O₄
• Molecular Weight: 384.516
• Mol file: 916067-33-9.mol

Synonyms:(S)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester

Chemical Property of (S)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester

There total 2 articles about (S)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethylfuran (14920-89-9) + (1R,3R,4S)-8-phenylmenthyl glyoxylate (84312-20-9) → (R)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester + (S)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester (916067-33-9)

Guidance literature:

With magnesium bromide; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/ol061943p

Reference yield:

di<(1R,2S,5R)-8-phenylmenthyl> fumarate (86253-91-0,98524-58-4) → (S)-hydroxy-(4,5-dimethyl-furan-2-yl)-acetic acid (1'R,2'S,5'R)-8'-phenylmenthyl ester (916067-33-9)

Guidance literature:

Multi-step reaction with 2 steps

1: O₃

2: MgBr₂*0.5H₂O / CH₂Cl₂ / 3 h / 20 °C

With ozone; magnesium bromide; In dichloromethane; 2: Friedel-Crafts reaction;

DOI:10.1021/ol061943p

upstream raw materials:

2,3-dimethylfuran

(1R,3R,4S)-8-phenylmenthyl glyoxylate

di<(1R,2S,5R)-8-phenylmenthyl> fumarate