tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

Base Information

Chemical Name:tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate
CAS No.:882856-84-0
Molecular Formula:C₂₄H₂₆F₃N₅O₃
Molecular Weight:489.497
Hs Code.:

Synonyms:tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

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Chemical Property of tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

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Technology Process of tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

There total 17 articles about tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 882856-83-9
tert-butyl [(3R,4R)-1-[5-amino-6-(aminocarbonyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

: 122-51-0
orthoformic acid triethyl ester

: 882856-84-0
tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

Guidance literature:: In toluene; for 48h; Heating / reflux;

Reference yield:

: 882856-76-0
tert-butyl (3R,4R)-1-benzyl-4-(2,4,5-trifluorophenyl)piperidin-3-ylcarbamate

: 882856-84-0
tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd(OH)2 / methanol

2: DIEA / toluene / Heating

3: toluene / Heating

With hydrogen; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; toluene;
DOI:10.1016/j.bmcl.2007.05.087

Reference yield:

: C₂₀H₁₈F₃NO₃

: 882856-84-0
tert-butyl [(3R,4R)-1-(2-methyl-4-oxo-3,4-dihydropyrido[3,2-d]pyrimidine-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-yl]carbamate

Guidance literature:: Multi-step reaction with 10 steps

1.1: aq. LiOH / tetrahydrofuran; methanol / 60 °C

2.1: diphenyl phosphoryl azide; triethylamine / toluene / Heating

3.1: Heating

4.1: H₂ / Pd(OH)2 / methanol / 2327.23 Torr

5.1: BH₃ / tetrahydrofuran / Heating

5.2: HCl / tetrahydrofuran / Heating

6.1: tetrahydrofuran; ethyl acetate / Heating

7.1: H₂ / Pd(OH)2 / methanol

8.1: DIEA / toluene / Heating

9.1: toluene / Heating

With lithium hydroxide; diphenyl phosphoryl azide; borane; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In tetrahydrofuran; methanol; ethyl acetate; toluene; 2.1: Curtius rearrangement;
DOI:10.1016/j.bmcl.2007.05.087