3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

Base Information

Chemical Name:3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole
CAS No.:1272644-64-0
Molecular Formula:C₂₆H₃₇NO₇Si
Molecular Weight:503.668
Hs Code.:

Synonyms:3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

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Chemical Property of 3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

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Technology Process of 3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

There total 3 articles about 3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 13400-02-7
3,4,5-trimethoxy styrene

: 1246651-17-1
4-(tert-butyl-dimethyl-silyloxy)-3,5-dimethoxybenzaldehyde oxime

: 1272644-64-0
3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

Guidance literature:: With sodium hypochlorite; triethylamine; In dichloromethane; water; at 0 - 20 ℃; for 25h; Inert atmosphere;
DOI:10.1016/j.ejmech.2010.12.004

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1272644-64-0
3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 20 °C

2: sodium hypochlorite; triethylamine / dichloromethane; water / 25 h / 0 - 20 °C / Inert atmosphere

With sodium hypochlorite; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; water; mineral oil;
DOI:10.1016/j.ejmech.2010.12.004

Reference yield:

: 106852-80-6
4-(t-butyldimethylsilyloxy)-3,5-dimethoxybenzaldehyde

: 1272644-64-0
3-(4-(tert-butyldimethylsilyloxy)-3,5-dimethoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydroisoxazole

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride; sodium hydrogencarbonate / 6 h / 20 °C

2: sodium hypochlorite; triethylamine / dichloromethane; water / 25 h / 0 - 20 °C / Inert atmosphere

With sodium hypochlorite; hydroxylamine hydrochloride; sodium hydrogencarbonate; triethylamine; In dichloromethane; water;
DOI:10.1016/j.ejmech.2010.12.004