Technology Process of (2S,4'R,8'R)-2',5',11'-α-tocotrienol benzyl ether
There total 14 articles about (2S,4'R,8'R)-2',5',11'-α-tocotrienol benzyl ether which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium dithionite; water; Aliquat 336; sodium hydrogencarbonate;
In
cyclohexane;
Yield given;
Heating;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, hexane, 0 deg C, 2 h
2: 97.7 percent / NaH, Pd(PPh3)4 / tetrahydrofuran / -78 - 20 °C
3: DIBAL / toluene / 1 h / 0 °C
4: pyridine / 20 h / Ambient temperature
5: DBN / diethyl ether / Ambient temperature
6: Na2S2O4, NaHCO3, H2O, Aliquot 336 / cyclohexane / Heating
With
pyridine; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; sodium dithionite; 2,6-dichloro-benzonitrile; water; Aliquat 336; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate;
In
tetrahydrofuran; diethyl ether; cyclohexane; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90.4 percent / K2CO3 / dimethylformamide / 120 h / Ambient temperature
2: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 15 min, 2.) THF, hexane, 0 deg C, 2 h
3: 97.7 percent / NaH, Pd(PPh3)4 / tetrahydrofuran / -78 - 20 °C
4: DIBAL / toluene / 1 h / 0 °C
5: pyridine / 20 h / Ambient temperature
6: DBN / diethyl ether / Ambient temperature
7: Na2S2O4, NaHCO3, H2O, Aliquot 336 / cyclohexane / Heating
With
pyridine; tetrakis(triphenylphosphine) palladium(0); n-butyllithium; sodium dithionite; 2,6-dichloro-benzonitrile; water; Aliquat 336; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; potassium carbonate;
In
tetrahydrofuran; diethyl ether; cyclohexane; N,N-dimethyl-formamide; toluene;
