58846-72-3

Upstream product

• 58846-71-2 (-)-(S)-methyl(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetate 
• 100-44-7 benzyl chloride 
• 865444-18-4 4-(benzyloxy)-2,3,5-trimethyl-6-(3-methylbut-3-en-1-yl)phenol 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 53730-39-5 (S)-(-)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-acetic acid 

Downstream Products

• 58846-73-4 (S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-acetaldehyde 
• 119775-99-4 (S)-1-<3,4-dihydro-2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-3'-phenylsulfonyl-2-propanone 
• 53730-41-9 (S)-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)acetic acid 
• 59965-06-9 Vitamin E benzyl ether 
• 119817-82-2 (S)-3-oxo-4-<3,4-dihydro-2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>butanoic acid methyl ester 
• 119817-85-5 (S)-5-[2-[3,4-dihydro-2,5,7,8-tetramethyl-6-phenylmethoxy-2H-1-benzopyran-2-yl]-1-hydroxyethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 119776-03-3 <2S-(4R,5E,8R)>-1-<2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-4,8,12-trimethyl-3-phenylsulfonyltrideca-2,5,11-triene 
• 162810-67-5 (2S,4'R,8'R)-2',5',11'-α-tocotrienol benzyl ether 
• 59-02-9 Tocopherol 
• 895518-38-4 vitamin E 
• 1406-70-8 (2R,4'RS,8'RS)-α-tocopheryl acetate 
• 60018-14-6 (S)-(-)-2-[6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl]ethanol 

Relevant academic research and scientific papers

Palladium-catalyzed domino-wacker-carbonylation reaction for the enantioselective synthesis of chromans and benzodioxins

A palladium-catalyzed domino reaction for the formation of chromans 9 as well as 10 and benzodioxins 13 is described starting from the alkenes 6 as well as 8 and the allyl phenyl ethers 12. The domino reaction comprises an enantioselective intramolecular

A MICROBIAL LIPASE BASED STEREOSELECTIVE SYNTHESIS OF (d)-α-TOCOPHEROL FROM (R)-CITRONELLAL AND (S)-(6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-YL)ACETIC ACID

A new sythesis of natural vitamin E (2R,4'R,8'R)-α-tocopherol) based on (R)-citronellal and (S)-(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetic acid is described.The citronellal is elaborated into an optically pure C13 allylic carbonate using a lipase catalyzed kinetic resolution to control the new chiral center.Palladium catalyzed coupling of the C13 carbonate with either a β-ketoester or β-ketosulphone derived from the chromanylacetic completes the assembly of the α-tocopherol skeleton.Appropriate functional group modifications are used to complete the synthesis.