1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one

Base Information

Chemical Name:1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one
CAS No.:1342834-36-9
Molecular Formula:C₂₃H₁₉FN₄O₂S
Molecular Weight:434.494
Hs Code.:

Synonyms:1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one

There total 4 articles about 1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1342834-34-7
1-((6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)-pyrrolidin-2-one

: 1342834-36-9
1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one

Guidance literature:: With iron; ammonium chloride; In methanol; water; for 3h; Reflux;

Reference yield:

: 1342834-32-5
2-(5-(chloromethyl)pyridin-2-yl)-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]-pyridine

: 1342834-36-9
1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: DIPEA / acetonitrile

2: ammonium chloride; sodium hydrogencarbonate; iron / ethyl acetate; water

With DIPEA; ammonium chloride; iron; sodium hydrogencarbonate; In water; ethyl acetate; acetonitrile;

Reference yield:

: 1342834-30-3
(6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methanol

: 1342834-36-9
1-((6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride

2: DIPEA / acetonitrile

3: ammonium chloride; sodium hydrogencarbonate; iron / ethyl acetate; water

With DIPEA; ammonium chloride; iron; sodium hydrogencarbonate; In thionyl chloride; water; ethyl acetate; acetonitrile;