Multi-step reaction with 6 steps
1: 1.) Mg, 2.) dilithium tetrachlorocopper(II) / 1.) THF, reflux, 2 h, 2.) a) THF, reflux, 2 h, b) THF, RT, 16 h
2: 96 percent / BBr3 / CH2Cl2 / 3 h / Ambient temperature
3: 1.) NaH / 1.) DMF, reflux, 2 h, 2.) DMF, reflux, 24 h
4: 61 percent / 1N aq. HCl / methanol / 3 h / Heating
5: 97 percent / pyridine / 48 h / Ambient temperature
6: 73 percent / NaH / dimethylformamide / 3 h / Ambient temperature
With
pyridine; hydrogenchloride; dilithium tetrachlorocuprate; boron tribromide; sodium hydride; magnesium;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00375a016