phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester

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Chemical Name:phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester
CAS No.:259185-61-0
Molecular Formula:C₅₆H₇₉N₂O₁₅P
Molecular Weight:1051.22
Hs Code.:

phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-<i>d</i>][1,3]dioxol-5-yl)-ethyl ester

Synonyms:phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester

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Chemical Property of phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester

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Technology Process of phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester

There total 6 articles about phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5'-O-(4,4'-dimethoxytrityl)thymidine 3'-(hexadecyl phosphate), sodium salt

: 18549-40-1
1,2-O-isopropylidene-α-D-glucofuranose

: 259185-61-0
phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester

Guidance literature:: With 1-methyl-1H-imidazole; Triphenylsilyl chloride; In pyridine; at 40 ℃;
DOI:10.1080/07328319908044627

Reference yield:

: 36653-82-4,124-29-8
1-Hexadecanol

: 259185-61-0
phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / MSNT / pyridine / 0.5 h / 20 °C

2: 92 percent / aq. NaOH / dioxane / 3 h / 20 °C

3: 90 percent / TPSCl; 1-methylimidazole / pyridine / 40 °C

With 1-methyl-1H-imidazole; sodium hydroxide; MSNT; Triphenylsilyl chloride; In 1,4-dioxane; pyridine; 1: Condensation / 2: Hydrolysis / 3: Condensation;
DOI:10.1080/07328319908044627

Reference yield:

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

: 259185-61-0
phosphoric acid 2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester hexadecyl ester 2-hydroxy-2-(6-hydroxy-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl)-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1,2,4-triazole; Et₃N; 1-methylimidazole / tetrahydrofuran / 0.17 h

2: H₂O / tetrahydrofuran

3: 100 percent / MSNT / pyridine / 0.5 h / 20 °C

4: 92 percent / aq. NaOH / dioxane / 3 h / 20 °C

5: 90 percent / TPSCl; 1-methylimidazole / pyridine / 40 °C

With 1,2,4-Triazole; 1-methyl-1H-imidazole; sodium hydroxide; MSNT; Triphenylsilyl chloride; water; triethylamine; In tetrahydrofuran; 1,4-dioxane; pyridine; 1: Condensation / 2: Hydrolysis / 3: Condensation / 4: Hydrolysis / 5: Condensation;
DOI:10.1080/07328319908044627