(S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Base Information

Chemical Name:(S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione
CAS No.:1370248-39-7
Molecular Formula:C₃₃H₃₂N₂O₅
Molecular Weight:536.627
Hs Code.:

Synonyms:(S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

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Chemical Property of (S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

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Technology Process of (S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

There total 7 articles about (S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1370248-38-6
(S)-4-benzhydryl-9-(benzyloxy)-N-methoxy-2-(2-methoxyethyl)-N-methyl-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide

: 75-16-1
methylmagnesium bromide

: 1370248-39-7
(S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Guidance literature:: In tetrahydrofuran; at -78 - -50 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b00861

Reference yield:

: 1370248-11-5
ethyl (S)-5-(benzyloxy)-1-(3-hydroxy-1,1-diphenylpropan-2-yl)-6-((2-methoxyethyl)carbamoyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

: 1370248-39-7
(S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 20 h / 20 °C / Cooling with ice

2.1: sodium hydroxide; water / ethanol / 1.17 h / 20 °C

3.1: chloroformic acid ethyl ester; triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Cooling with ice

3.2: 1 h / 20 °C

4.1: tetrahydrofuran / 0.5 h / -78 - -50 °C / Inert atmosphere

With water; chloroformic acid ethyl ester; triethylamine; triphenylphosphine; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1370248-13-7
(S)-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylic acid

: 1370248-39-7
(S)-7-acetyl-4-benzhydryl-9-(benzyloxy)-2-(2-methoxyethyl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloroformic acid ethyl ester; triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C / Cooling with ice

1.2: 1 h / 20 °C

2.1: tetrahydrofuran / 0.5 h / -78 - -50 °C / Inert atmosphere

With chloroformic acid ethyl ester; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;