2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester
CAS No.:1054658-49-9
Molecular Formula:C₂₄H₃₄O₆
Molecular Weight:418.53
Hs Code.:

Synonyms:2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester

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Technology Process of 2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester

There total 5 articles about 2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S)-3,4-dihydroxy-6-phenylhex-5-ynoic acid

: 1054658-49-9
2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 43 percent / p-toluenesulfonic acid / benzene / 1.5 h / 50 °C

2: 1.) p-toluenesulfonic acid, 2.) LiAlH₄ / 1.) THF, room temp., 3 h, 2.) Et₂O, room temp., overnight

3: 1.) pyridine, DMAP / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 3 h

With pyridine; dmap; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In benzene;
DOI:10.1021/jo960816b

Reference yield:

: 4440-01-1
lithium phenylacetylide

: 1054658-49-9
2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) NaBH₄ / 1.) THF, -78 deg C, 35 min, 2.) THF, EtOH, -78 deg C , 15 min

2: 43 percent / p-toluenesulfonic acid / benzene / 1.5 h / 50 °C

3: 1.) p-toluenesulfonic acid, 2.) LiAlH₄ / 1.) THF, room temp., 3 h, 2.) Et₂O, room temp., overnight

4: 1.) pyridine, DMAP / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 3 h

With pyridine; dmap; sodium tetrahydroborate; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In benzene;
DOI:10.1021/jo960816b

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1054658-49-9
2,2-Dimethyl-propionic acid (E)-(3S,4S)-4-acetoxy-6-phenyl-3-(tetrahydro-pyran-2-yloxy)-hex-5-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) p-toluenesulfonic acid, 2.) LiAlH₄ / 1.) THF, room temp., 3 h, 2.) Et₂O, room temp., overnight

2: 1.) pyridine, DMAP / 1.) CH₂Cl₂, 0 deg C, 3 h, 2.) CH₂Cl₂, 3 h

With pyridine; dmap; lithium aluminium tetrahydride; toluene-4-sulfonic acid;
DOI:10.1021/jo960816b