5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester
• CAS No.: 1161775-44-5
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.251
• Mol file: 1161775-44-5.mol

Synonyms:5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester

Chemical Property of 5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester

There total 5 articles about 5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

isocyanoacetic acid methyl ester (39687-95-1) + 3-(methoxymethyl)benzoyl chloride (199742-77-3) → 5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester (1161775-44-5)

Guidance literature:

With triethylamine; dmap; In tetrahydrofuran; for 21h; Reflux;

Reference yield:

5-(3-hydroxymethyl-phenyl)-oxazole-4-carboxylic acid (1161775-42-3) + methyl iodide (74-88-4) → 5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester (1161775-44-5)

Guidance literature:

5-(3-hydroxymethyl-phenyl)-oxazole-4-carboxylic acid; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 0 - 25 ℃; Inert atmosphere;

Reference yield:

3-methoxycarbonylbenzyl bromide (1129-28-8) → 5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid methyl ester (1161775-44-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol / 2 h / 20 - 50 °C / Inert atmosphere

1.2: 1.5 h / 50 °C

1.3: 20 °C / pH 2 - 3

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 1.83 h / 40 °C / Inert atmosphere

3.1: triethylamine / dmap / tetrahydrofuran / 21 h / Reflux

With thionyl chloride; triethylamine; dmap; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane;

upstream raw materials:

5-(3-hydroxymethyl-phenyl)-oxazole-4-carboxylic acid

methyl iodide

3-methoxymethyl-benzoic acid

3-methoxycarbonylbenzyl bromide

Downstream raw materials:

5-(3-methoxymethyl-phenyl)-oxazole-4-carboxylic acid

4-(bromomethyl)-5-(3-(methoxymethyl)phenyl)oxazole

(5-(3-(methoxymethyl)phenyl)oxazole-4-yl)methanol

(5-(3-(methoxymethyl)phenyl)-2-methyloxazole-4-yl)methanol