Technology Process of methyl 8-(1-(3,5-difluorophenylamino)ethyl)-2-(ethylsulfinyl)-4-oxo-4H-chromene-6-carboxylate
There total 10 articles about methyl 8-(1-(3,5-difluorophenylamino)ethyl)-2-(ethylsulfinyl)-4-oxo-4H-chromene-6-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: bromine / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere
2.1: triethylamine / palladium diacetate; (diphenylphosphin)ferrocene / diethyl ether; ethanol / 70 °C / Inert atmosphere
2.2: 2 h
3.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C
3.2: 5 °C
4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -50 - 0 °C / Inert atmosphere
4.2: 24 h / -20 - 20 °C
4.3: -50 °C
5.1: potassium carbonate / acetone / 2 h / 60 °C / Inert atmosphere
6.1: ISOPROPYLAMIDE / 50 °C
7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C / Cooling with ice
With
pyridine; bromine; sodium hexamethyldisilazane; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid;
(diphenylphosphin)ferrocene; palladium diacetate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ISOPROPYLAMIDE; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: triethylamine / palladium diacetate; (diphenylphosphin)ferrocene / diethyl ether; ethanol / 70 °C / Inert atmosphere
1.2: 2 h
2.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C
2.2: 5 °C
3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -50 - 0 °C / Inert atmosphere
3.2: 24 h / -20 - 20 °C
3.3: -50 °C
4.1: potassium carbonate / acetone / 2 h / 60 °C / Inert atmosphere
5.1: ISOPROPYLAMIDE / 50 °C
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C / Cooling with ice
With
pyridine; bromine; sodium hexamethyldisilazane; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid;
(diphenylphosphin)ferrocene; palladium diacetate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; ISOPROPYLAMIDE; acetone;
