8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Base Information

Chemical Name:8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide
CAS No.:1296271-32-3
Molecular Formula:C₂₅H₂₇F₂N₃O₄
Molecular Weight:471.504
Hs Code.:

Synonyms:8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

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Chemical Property of 8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

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Technology Process of 8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

There total 13 articles about 8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1296271-78-7
8-(1-(3,5-difluorophenylamino)ethyl)-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxylic acid

: 124-40-3
dimethyl amine

: 1296271-32-3
8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 29415-97-2
methyl 3-bromo-4-hydroxybenzoate

: 1296271-32-3
8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / palladium diacetate; (diphenylphosphin)ferrocene / diethyl ether; ethanol / 70 °C / Inert atmosphere

1.2: 2 h

2.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C

2.2: 5 °C

3.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -50 - 0 °C / Inert atmosphere

3.2: 24 h / -20 - 20 °C

3.3: -50 °C

4.1: potassium carbonate / acetone / 2 h / 60 °C / Inert atmosphere

5.1: ISOPROPYLAMIDE / 50 °C

6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C / Cooling with ice

7.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 7 h / 20 - 75 °C

8.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 - 35 °C / Cooling with ice

8.2: pH 2 - 3

9.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 20 °C

With 4-methyl-morpholine; pyridine; water; bromine; sodium hexamethyldisilazane; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; (diphenylphosphin)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1296271-32-3
8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-((S)-3-methylmorpholino)-4-oxo-4H-chromene-6-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: bromine / dichloromethane / 36 h / 0 - 20 °C / Inert atmosphere

2.1: triethylamine / palladium diacetate; (diphenylphosphin)ferrocene / diethyl ether; ethanol / 70 °C / Inert atmosphere

2.2: 2 h

3.1: bromine; pyridine / dichloromethane / 2 h / 0 - 20 °C

3.2: 5 °C

4.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -50 - 0 °C / Inert atmosphere

4.2: 24 h / -20 - 20 °C

4.3: -50 °C

5.1: potassium carbonate / acetone / 2 h / 60 °C / Inert atmosphere

6.1: ISOPROPYLAMIDE / 50 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 20 °C / Cooling with ice

8.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 7 h / 20 - 75 °C

9.1: sodium hydroxide; water / tetrahydrofuran; methanol / 3 h / 20 - 35 °C / Cooling with ice

9.2: pH 2 - 3

10.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / N,N-dimethyl-formamide / 1 h / 20 °C

With 4-methyl-morpholine; pyridine; water; bromine; sodium hexamethyldisilazane; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; (diphenylphosphin)ferrocene; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ISOPROPYLAMIDE; N,N-dimethyl-formamide; acetone; acetonitrile;