(R)-β,β-diphenyl-α-alanine hydrochloride

Base Information

• Chemical Name: (R)-β,β-diphenyl-α-alanine hydrochloride
• CAS No.: 143060-93-9
• Molecular Formula: C₁₅H₁₅NO₂*ClH
• Molecular Weight: 277.751
• Mol file: 143060-93-9.mol

Synonyms:(R)-β,β-diphenyl-α-alanine hydrochloride

Chemical Property of (R)-β,β-diphenyl-α-alanine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-β,β-diphenyl-α-alanine hydrochloride

There total 9 articles about (R)-β,β-diphenyl-α-alanine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(tert-butoxycarbonyl)-3,3-diphenyl-D-alanine (143060-31-5) → (R)-β,β-diphenyl-α-alanine hydrochloride (143060-93-9)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 72h;

DOI:10.1016/00404-0399(50)1029H-

Reference yield: 77.0%

(2R)-Azido-3,3-diphenylpropionic acid (142956-11-4) → (R)-β,β-diphenyl-α-alanine hydrochloride (143060-93-9)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 20h; under 2585.7 Torr;

DOI:10.1016/S0040-4039(00)92070-7

Reference yield:

3,3-Diphenylpropionic acid (606-83-7) → (R)-β,β-diphenyl-α-alanine hydrochloride (143060-93-9)

Guidance literature:

Multi-step reaction with 5 steps

1: iPr₂NEt / tetrahydrofuran / 1 h / -78 to 0 deg C

2: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 0 deg C

3: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min

4: 99 percent / LiOH*H₂O, 30percent aq. H₂O₂ / tetrahydrofuran; H₂O / 1 h / 0 °C

5: 77 percent / HCl, H₂ / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr

With hydrogenchloride; lithium hydroxide; n-butyllithium; 2,4,6-Triisopropylbenzenesulfonyl azide; hydrogen; dihydrogen peroxide; potassium hexamethylsilazane; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; water;

DOI:10.1016/S0040-4039(00)92070-7

upstream raw materials:

(2R)-Azido-3,3-diphenylpropionic acid

N-(tert-butoxycarbonyl)-3,3-diphenyl-D-alanine

N-[(R)-1-((R)-4-Benzyl-2-oxo-oxazolidine-3-carbonyl)-2,2-diphenyl-ethyl]-acetamide

3,3-Diphenylpropionic acid

Downstream raw materials:

(R)-2-Methoxycarbonylamino-3,3-diphenyl-propionic acid

N-(tert-butoxycarbonyl)-3,3-diphenyl-D-alanine