3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid

Base Information

Chemical Name:3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid
CAS No.:261364-74-3
Molecular Formula:C₂₅H₄₀N₂O₈
Molecular Weight:496.601
Hs Code.:

3-(2-{2-[2-(2-<i>tert</i>-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid

Synonyms:3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid

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Chemical Property of 3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid

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Technology Process of 3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid

There total 5 articles about 3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 261364-73-2
{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethyl}-carbamic acid 2-(1,1-dimethyl-3-oxo-propyl)-3,5-dimethyl-phenyl ester

: 261364-74-3
3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid

Guidance literature:: With sodium dihydrogenphosphate; In acetonitrile; at 0 ℃; for 1h;
DOI:10.1021/jm990498j

Reference yield:

: 134098-64-9
2‐{3‐[(O‐tert‐butyldimethylsilyl)hydroxy]‐1,1‐dimethylpropyl}‐3,5‐dimethylphenol

: 261364-74-3
3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / CHCl₃ / 3 h / 35 - 40 °C

2: 720 mg / pyridine / CHCl₃ / 35 - 40 °C

3: 99 percent / aq. AcOH / tetrahydrofuran / 1 h / 20 °C

4: 68 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 °C

5: 80 percent / 80percent aq. NaClO₂; NaH₂PO₄ / acetonitrile / 1 h / 0 °C

With pyridine; sodium dihydrogenphosphate; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; chloroform; acetonitrile; 1: chloroformylation / 2: Condensation / 3: desilylation / 4: Oxidation / 5: Oxidation;
DOI:10.1021/jm990498j

Reference yield:

: C₂₀H₃₃ClO₃Si

: 261364-74-3
3-(2-{2-[2-(2-tert-butoxycarbonylamino-ethoxy)-ethoxy]-ethylcarbamoyloxy}-4,6-dimethyl-phenyl)-3-methyl-butyric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 720 mg / pyridine / CHCl₃ / 35 - 40 °C

2: 99 percent / aq. AcOH / tetrahydrofuran / 1 h / 20 °C

3: 68 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 °C

4: 80 percent / 80percent aq. NaClO₂; NaH₂PO₄ / acetonitrile / 1 h / 0 °C

With pyridine; sodium dihydrogenphosphate; acetic acid; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; chloroform; acetonitrile; 1: Condensation / 2: desilylation / 3: Oxidation / 4: Oxidation;
DOI:10.1021/jm990498j