trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran

Base Information

Chemical Name:trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran
CAS No.:134186-90-6
Molecular Formula:C₃₀H₃₆O₈S
Molecular Weight:556.677
Hs Code.:

Synonyms:trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran

Suppliers and Price of trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran

There total 10 articles about trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 134169-13-4
(-)-(1S)-1-hydroxy-1-<3-(methylsulfonyl)-4-n-propoxy-5-(benzyloxy)phenyl>-4-(3,4,5-trimethoxyphenyl)butan-4-one

: 134186-90-6
trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran

: 143395-23-7
(2S,5R)-2-(3-Benzyloxy-5-methanesulfonyl-4-propoxy-phenyl)-5-(3,4,5-trimethoxy-phenyl)-tetrahydro-furan

Guidance literature:: With sodium tetrahydroborate; In ethanol; dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm00097a005

Reference yield:

: 50773-56-3
3-benzyloxy-4-hydroxybenzaldehyde

: 134186-90-6
trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran

Guidance literature:: Multi-step reaction with 7 steps

1: 1.3 kg / bromine, sodium acetate / acetic acid / 45 h

2: 76 percent / copper / pyridine / 16 h / 95 °C

3: 1.04 kg / K₂CO₃ / dimethylformamide / 75 °C

4: 1.45 kg / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide (ETB), triethylamine / 2 h / 90 °C

5: 65 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

6: 73 percent / lithium aluminium hydride, (S)-(-)-binaphthol / ethanol; tetrahydrofuran / 1.5 h

7: 55 percent / NaBH₄ / CH₂Cl₂; ethanol / 1 h / Ambient temperature

With sodium tetrahydroborate; lithium aluminium tetrahydride; bromine; (S)-[1,1']-binaphthalenyl-2,2'-diol; sodium acetate; copper; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00097a005

Reference yield:

: 4815-96-7
3-bromo-4-hydroxy-5-benzyloxybenzaldehyde

: 134186-90-6
trans-2-(3-benzyloxy-4-propoxy-5-methylsulfonylphenyl)-5-(3,4,5-trimethoxyphenyl)-tetrahydrofuran

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / copper / pyridine / 16 h / 95 °C

2: 1.04 kg / K₂CO₃ / dimethylformamide / 75 °C

3: 1.45 kg / 3-ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide (ETB), triethylamine / 2 h / 90 °C

4: 65 percent / 3-chloroperbenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

5: 73 percent / lithium aluminium hydride, (S)-(-)-binaphthol / ethanol; tetrahydrofuran / 1.5 h

6: 55 percent / NaBH₄ / CH₂Cl₂; ethanol / 1 h / Ambient temperature

With sodium tetrahydroborate; lithium aluminium tetrahydride; (S)-[1,1']-binaphthalenyl-2,2'-diol; copper; 3-ethyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazolium bromide; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; pyridine; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00097a005