(2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

Base Information

Chemical Name:(2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid
CAS No.:1241589-35-4
Molecular Formula:C₂₉H₂₇BrN₂O₆
Molecular Weight:579.447
Hs Code.:

Synonyms:(2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

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Chemical Property of (2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

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Technology Process of (2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

There total 4 articles about (2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1213399-90-6
(S)-2-(3-bromo-4-hydroxyphenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

: 189816-05-5
4-chloro-7-methoxy-2-phenylquinoline

: 1241589-35-4
(2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 64 ℃; for 1092h; Inert atmosphere;
DOI:10.1016/j.bmc.2010.05.027

Reference yield: 37.0%

: 1213399-90-6
(S)-2-(3-bromo-4-hydroxyphenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

: 1428537-42-1
4-fluoro-7-methoxy-2-phenylquinoline

: 1241589-35-4
(2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

Guidance literature:: (S)-2-(3-bromo-4-hydroxyphenyl)-2-((tert-butoxycarbonyl)amino)acetic acid; With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 0.166667h;

4-fluoro-7-methoxy-2-phenylquinoline; In dimethyl sulfoxide; at 64 ℃; for 6h; Reagent/catalyst; Temperature; Catalytic behavior; Inert atmosphere;
DOI:10.1021/jo400255m

Reference yield:

: 20430-72-2,189816-04-4
7-methoxy-2-phenylquinolin-4-ol

: 1241589-35-4
(2S)-2-(3-bromo-4-((7-methoxy-2-phenylquinolin-4-yl)oxy)phenyl)-2-((tert-butoxycarbonyl)amino)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: cesium fluoride / toluene; 1,4-dioxane / 168 h / 50 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; t-BuBrettPhos; cesium fluoride / toluene; 1,4-dioxane / 0.5 h / 180 °C / Microwave irradiation

3.1: potassium tert-butylate / dimethyl sulfoxide / 0.17 h / 20 °C

3.2: 6 h / 64 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; t-BuBrettPhos; potassium tert-butylate; cesium fluoride; In 1,4-dioxane; dimethyl sulfoxide; toluene;
DOI:10.1021/jo400255m