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189816-05-5

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189816-05-5 Usage

General Description

4-Chloro-7-methoxy-2-phenylquinoline is a chemical compound with the molecular formula C16H11ClNO. It is a member of the quinoline family and contains a chlorine and a methoxy group attached to the quinoline ring, as well as a phenyl group. 4-Chloro-7-methoxy-2-phenylquinoline has potential applications in pharmaceuticals and medicinal chemistry due to its structural features and potential biological activities. The presence of the chloro and methoxy groups may influence the compound's pharmacokinetic and pharmacodynamic properties. Further research is necessary to explore the potential uses and properties of 4-Chloro-7-methoxy-2-phenylquinoline in the development of new drugs and therapeutic agents.

Check Digit Verification of cas no

The CAS Registry Mumber 189816-05-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,9,8,1 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 189816-05:
(8*1)+(7*8)+(6*9)+(5*8)+(4*1)+(3*6)+(2*0)+(1*5)=185
185 % 10 = 5
So 189816-05-5 is a valid CAS Registry Number.
InChI:InChI=1/C16H12ClNO/c1-19-12-7-8-13-14(17)10-15(18-16(13)9-12)11-5-3-2-4-6-11/h2-10H,1H3

189816-05-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloro-7-methoxy-2-phenylquinoline

1.2 Other means of identification

Product number -
Other names 2-phenyl-4-chloro-7-methoxy-quinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:189816-05-5 SDS

189816-05-5Relevant articles and documents

Hepatitis C Virus Inhibitors

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Page/Page column 27-28, (2009/12/02)

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

Discovery of novel, potent and bioavailable proline-urea based macrocyclic HCV NS3/4A protease inhibitors

Vendeville, Sandrine,Nilsson, Magnus,Kock, Herman de,Lin, Tse-I,Antonov, Dmitry,Classon, Bjoern,Ayesa, Susana,Ivanov, Vladimir,Johansson, Per-Ola,Kahnberg, Pia,Eneroth, Anders,Wikstrom, Kristina,Vrang, Lotta,Edlund, Michael,Lindstroem, Stefan,Vreken, Wim Van de,McGowan, David,Tahri, Abdellah,Hu, Lili,Lenz, Oliver,Delouvroy, Frederic,Dooren, Marleen Van,Kindermans, Natalie,Surleraux, Dominique,Wigerinck, Piet,Rosenquist, Asa,Samuelsson, Bertil,Simmen, Kenneth,Raboisson, Pierre

scheme or table, p. 6189 - 6193 (2009/08/07)

A novel series of P3-truncated macrocyclic HCV NS3/4A protease inhibitors containing a P2 proline-urea or carbamate scaffold was synthesized. Very potent inhibitors were obtained through the optimization of the macrocycle size, urea and proline substitution, and bioisosteric replacement of the P1 carboxylic acid moiety. Variation of the lipophilicity by introduction of small lipophilic substituents resulted in improved PK profiles, ultimately leading to compound 13Bh, an extremely potent (Ki = 0.1 nM, EC50 = 4.5 nM) and selective (CC50 (Huh-7 cells) > 50 μM) inhibitor, displaying an excellent PK profile in rats characterized by an oral bioavailability of 54% and a high liver exposure after oral administration.

Substituted cycloalkyl P1' hepatitis C virus inhibitors

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Page/Page column 20, (2010/02/06)

The present invention relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and methods for using these analogs in the treatment of HCV infection.

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