N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide

Base Information

Chemical Name:N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide
CAS No.:1431386-69-4
Molecular Formula:C₁₉H₁₅F₄N₃O
Molecular Weight:377.341
Hs Code.:

Synonyms:N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide

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Chemical Property of N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide

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Technology Process of N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide

There total 3 articles about N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.3%

: 1431386-83-2
4-(3-(difluoromethyl)-1-methyl-H-pyrazol-5-yl)-3-fluoroaniline

: 21900-43-6
4-fluoro-2-methylbenzoyl chloride

: 1431386-69-4
N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 129922-58-3
1-methyl-3-difluoromethyl-5-hydroxy-1H-pyrazole

: 1431386-69-4
N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -40 - -30 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / acetonitrile; 1,4-dioxane; water / 6 h / 80 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 1431386-82-1
C₆H₅F₅N₂O₃S

: 1431386-69-4
N-(4-(3-(difluoromethyl)-1-methyl-1H-pyrazol-5-yl)-3-fluorophenyl)-4-fluoro-2-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium phosphate / acetonitrile; 1,4-dioxane; water / 6 h / 80 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; acetonitrile;